It now seems to only happen the first time I minimize the audio player and open a browsing tab and then doesn't happen again until I close the music player and then the UAC windows will sometimes crackle.
I'm also running the latest AMD Chipset drivers ( 1.) and they have seemed to mostly eliminate the crackling. I took your advice and I changed the LLC from 'Auto' to 'Normal'. Running the ram at JEDEC default of 2133 doesn't help with the crackling. Thank you for the reply, I already set the cpu and nb voltage from 'Auto' to 'Normal' and I see about ~1.464v spikes with the single core boost, and a constant voltage of ~1.452v during audio playback (although my cpu will max at only 44 multiplier instead of 45 when running my ram XMP 3600). Update2: It seems it doesn't matter what game I run, it still stutters/crackles with remote play, I guess it just randomly was working fine when I tested Division 2 and BFV, as I tried them again and they're both doing it.
Something else I noticed is that if SMT is disabled, windows performance monitor no longer correctly displays the clock speed and it shows just the base speed (in my case 3.89) Update: Disabling SMT did not fix the issue as I originally thought, I have no idea why that one bootup it worked flawlessly but I have yet to get it to work normally since. This issue definitely cannot be related to the MBox as it's not even plugged in when playing remotely (it uses some form of passthrough via the nvidia drivers). The other problem is that there is a large amount of stuttering + audio crackling/popping when trying to play a game remotely, via nvidia gamestream. I made a post on the Avid forums but I have a feeling nothing will be done even if it somehow is on their end as all their USB/Firewire Audio Interfaces are EOL after 2019. Disabling SMT has not fixed this issue for me sadly. Changing the power plan to Ryzen High Performance, or even the regular High Performance profile had no effect.
I don't have any traditional PC style speakers to test the onboard audio and only 1/4" headphones (I'll try to borrow some 1/8" headphones from a friend when I can). This didn't happen on my very old i5-2500k system so even though Avid drivers are not generally regarded as the best, I don't think they are to blame in this instance. It thankfully doesn't happen when playing games, but when playing music or at desktop, such as when a UAC confirmation window pops up, there is more often than not a terrible crackling/popping sound along with it. The audio device I'm using is an Avid MBox 3. I've been running into a stuttering/popping issue with my new AMD 3800x system.